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A Repeat Offender: Epstein- Barr Virus in Autoimmunity and Other Disease Mechanisms

Professor John B. Harley

Director, Centre for Autoimmune Genomics and Etiology Cincinnati Children’s Hospital, Ohio, USA

John Harley is a rheumatologist and biochemist with special clinical and research interests in the genetic etiology of inflammatory diseases. His experimental focus is the many genetic effects and environmental causes of systemic lupus erythematosus (SLE) and related inflammatory diseases. Through this work, nearly 50 genes are known and Epstein Barr virus has been identified to trigger the systemic autoimmunity of lupus. Dr. Harley also builds infrastructure with which to do high throughput genotyping, expression analysis, and epigenetics, which he makes available to his colleagues from around the world. In recent experiments, Dr. Harley organized the logistics of managing >18,000 subjects at >30,000 genetic markers, 3200 subjects at 1.2 million markers, and 10,000 subjects at 196,000 markers. Dr. Harley is committed to all of the steps between association detection through replication and toward identifying the possible functional genetic variants and to pursuing their biology.

Friday 10th August 3:00 pm - 5:00 pm
Ground Floor Function Room Flinders Centre for Innovation in Cancer
Light refreshments provided

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